Maternal Serum Invasive Trophoblast Antigen and First-Trimester Down Syndrome Screening
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چکیده
منابع مشابه
Maternal serum invasive trophoblast antigen and first-trimester Down syndrome screening.
BACKGROUND In the United States, Down syndrome screening is still performed mainly in the second trimester, using 3 or 4 markers. Moving screening into the first trimester has the advantage of earlier diagnosis. Currently, first-trimester screening typically includes maternal serum pregnancy-associated plasma protein-A (PAPP-A), the free beta-subunit of human chorionic gonadotropin (free beta),...
متن کاملSecond-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening.
Immunosuppressive Drug Monitoring. Ther Drug Monit 2002;24:59–67. 12. Novartis. Neoral C-2 monitoring: scientific evidence and clinical validation. http://www.transplantation-schweiz.ch/e/sandimmun/Scientific_Monograph. pdf (accessed June 2004). 13. Morris RG, Russ GR, Cervelli MJ, Juneja R, McDonal SP, Mathew TH. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclo...
متن کاملInvasive trophoblast antigen (hyperglycosylated human chorionic gonadotropin) as a first-trimester serum marker for Down syndrome.
and basic urine analysis. All were asymptomatic and underwent a complete examination by a cardiologist, including a visit, standard 12-lead electrocardiogram, Doppler echocardiographic examination, and a bicycle stress test (when older than 50 years), which excluded silent heart disease. The median ACCESS and TRIAGE BNP concentrations were 10.5 ng/L (range, 1–53 ng/L; 97.5th percentile, 45 ng/L...
متن کاملMaternal serum invasive trophoblast antigen (hyperglycosylated hCG) as a screening marker for Down syndrome during the second trimester.
BACKGROUND Approximately two million pregnancies in the United States are screened for Down syndrome annually by use of second-trimester maternal serum markers. At present, a combination of four markers can identify 75% of affected pregnancies when 5% of screened women are classified as candidates for amniocentesis. Although not currently included in screening panels, invasive trophoblast antig...
متن کاملADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.
BACKGROUND A Disintegrin And Metalloprotease 12 (ADAM 12) is a glycoprotein synthesised by placenta and it has been shown to be a potential first-trimester maternal serum marker for Down syndrome (DS) in two small series. Here we analyse further, the potential of ADAM 12 as a marker for DS in a large collection of first-trimester serum samples. MATERIALS AND METHODS The concentration of ADAM ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2005
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2005.050567